PhD. In bioinformatics. Study of bacterial polyketide synthases

University Claude Bernard

Lyon, France

2006 - 2003

• Joint supervision industry/ university (CIFRE)

Master in bioinformatics (french “DESS”)

University of Rouen

Rouen, France

2003 - 2001

• apprenticeship over one year in industry

Research Scientist

University of Luxembourg

Belvaux, Luxembourg

2019 - 2014

• Head of the bioinformatic core for the LSRU

Postdoctoral fellow

Centre for GeoGenetics

Copenhagen, Denmark

2014 - 2012

• Bioanalyst, equids evolution and ancient DNA
• Marie-Curie Fellowship

Postdoctoral fellow

Centre for GeoGenetics

Copenhagen, Denmark

2012 - 2010

• ancient DNA

Research Scientist

LibraGen SA.

Toulouse, France

2010 - 2006

• Biocatalysis, bioinformatics
• System administration

PhD Candidate

LibraGen SA.

Lyon, France

2006 - 2003

• bioinformatics and metagenomic
• System administration

Biostatistics 2. Bachelor in Life Sciences

University of Luxembourg

Belvaux, Luxembourg

2019 - 2014

• 60 hours with half hands-on. 7 ECTS
• https://biostat2.uni.lu/

Workshop on data processing with R tidyverse

University of Luxembourg

Belvaux, Luxembourg

2019 - 2016

• Four days course with half hands-on. 2 ECTS
• With Dr. Roland Krause via Elixir Luxembourg
• https://rworkshop.uni.lu/

Workshop on ancient DNA analysis

Danish Technology University

Lyngby, Denmark

2014 - 2012

• Practical course in the Next Generation Sequencing Analysis

Paleogenomic workflows at the Center for GeoGenetics

CNRS Summer School

Cargese, France

2010

• Lectures and hands-on sessions

Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny

Cappellini, E. Welker, F. Pandolfi, L. Ramos-Madrigal, J. Samodova, D. Ruther, P. L. Fotakis, A. K. Lyon, D. Moreno-Mayar, J. V. Bukhsianidze, M. Rakownikow Jersie-Christensen, R. Mackie, M. Ginolhac, A. Ferring, R. Tappen, M. Palkopoulou, E. Dickinson, M. R. Stafford, T. W. Chan, Y. L. Gotherstrom, A. Nathan, S. K. S. S. Heintzman, P. D. Kapp, J. D. Kirillova, I. Moodley, Y. Agusti, J. Kahlke, R. D. Kiladze, G. Martinez-Navarro, B. Liu, S. Sandoval Velasco, M. Sinding, M. S. Kelstrup, C. D. Allentoft, M. E. Orlando, L. Penkman, K. Shapiro, B. Rook, L. Dalen, L. Gilbert, M. T. P. Olsen, J. V. Lordkipanidze, D. and Willerslev, E. Nature 574, 103–107

N/A

2019

Identification of genes under dynamic post-transcriptional regulation from time-series epigenomic data

Becker, J. C. Gerard, D. Ginolhac, A. Sauter, T. Sinkkonen, L. et al. Epigenomics 11, 619–638

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TREM2 triggers microglial density and age-related neuronal loss

Linnartz-Gerlach, B. Bodea, L. G. Klaus, C. Ginolhac, A. Halder, R. et al. Glia 67, 539–550

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Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency

Gerard, D. Schmidt, F. Ginolhac, A. Schmitz, M. Halder, R. et al. Nucleic Acids Res. 47, 1141–1163

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N/A

Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets

Kirchmeyer, M. Servais, F. A. Hamdorf, M. Nazarov, P. V. Ginolhac, A. Halder, R. Vallar, L. Glanemann, M. Rubie, C. Lammert, F. et al. J. Leukoc. Biol. 104, 987–1002

N/A

2018

The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by \(\alpha\)-PD-L1 or \(\alpha\)-IL6 antibodies

Rolvering, C. Zimmer, A. D. Ginolhac, A. Margue, C. Kirchmeyer, M. Servais, F. Hermanns, H. M. Hergovits, S. Nazarov, P. V. Nicot, N. et al. J. Leukoc. Biol. 104, 969–985

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The miR-371 similar to 373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis

Ullmann, P. Rodriguez, F. Schmitz, M. Meurer, S. K. Qureshi-Baig, K. Felten, P. Ginolhac, A. Antunes, L. Frasquilho, S. Zugel, N. et al. Cancer Res. 78, 3793–3808

N/A

N/A

Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence

Letellier, E. Schmitz, M. Ginolhac, A. Rodriguez, F. Ullmann, P. et al. Br. J. Cancer 117, 1689–1701

N/A

2017

Crosstalk between different family members: IL27 recapitulates IFN \(\gamma\) responses in HCC cells, but is inhibited by IL6-type cytokines

Rolvering, C. Zimmer, A. D. Kozar, I. Hermanns, H. M. Letellier, E. Vallar, L. Nazarov, P. V. Nicot, N. Ginolhac, A. Haan, S. et al. Biochim Biophys Acta Mol Cell Res 1864, 516–526

N/A

N/A

Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production

Ullmann, P. Qureshi-Baig, K. Rodriguez, F. Ginolhac, A. Nonnenmacher, Y. Ternes, D. Weiler, J. Gabler, K. Bahlawane, C. Hiller, K. et al. Oncotarget 7, 65454–65470

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2016

Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells

Dorosz, S. A. Ginolhac, A. Kahne, T. Naumann, M. Sauter, T. et al. Mediators Inflamm. 2015, 737310

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2015

Evolutionary Genomics and Conservation of the Endangered Przewalski’s Horse

Der Sarkissian, C. Ermini, L. Schubert, M. Yang, M. A. Librado, P. Fumagalli, M. Jonsson, H. Bar-Gal, G. K. Albrechtsen, A. Vieira, F. G. Petersen, B. Ginolhac, A. Seguin-Orlando, A. Magnussen, K. Fages, A. Gamba, C. Lorente-Galdos, B. Polani, S. Steiner, C. Neuditschko, M. Jagannathan, V. Feh, C. Greenblatt, C. L. Ludwig, A. Abramson, N. I. Zimmermann, W. Schafberg, R. Tikhonov, A. Sicheritz-Ponten, T. Willerslev, E. Marques-Bonet, T. Ryder, O. A. McCue, M. Rieder, S. Leeb, T. Slatkin, M. and Orlando, L. Curr. Biol. 25, 2577–2583

N/A

N/A

Prehistoric genomes reveal the genetic foundation and cost of horse domestication

Schubert, M. Jonsson, H. Chang, D. Der Sarkissian, C. Ermini, L. Ginolhac, A. Albrechtsen, A. Dupanloup, I. Foucal, A. Petersen, B. et al. Proc. Natl. Acad. Sci. U.S.A. 111, E5661–5669

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2014

Speciation with gene flow in equids despite extensive chromosomal plasticity

Jonsson, H. Schubert, M. Seguin-Orlando, A. Ginolhac, A. Petersen, L. Fumagalli, M. Albrechtsen, A. Petersen, B. Korneliussen, T. S. Vilstrup, J. T. et al. Proc. Natl. Acad. Sci. U.S.A. 111, 18655–18660

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Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX

Schubert, M. Ermini, L. Der Sarkissian, C. Jonsson, H. Ginolhac, A. Schaefer, R. Martin, M. D. Fernandez, R. Kircher, M. McCue, M. et al. Nat Protoc 9, 1056–1082

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A comparative study of ancient environmental DNA to pollen and macrofossils from lake sediments reveals taxonomic overlap and additional plant taxa

Pedersen, Mikkel Winther Ginolhac, Aurelien Orlando, Ludovic Olsen, Jesper Andersen, Kenneth et al. Quaternary Science Reviews 75, 161–168

N/A

2013

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse

Orlando, L. Ginolhac, A. Zhang, G. Froese, D. Albrechtsen, A. Stiller, M. Schubert, M. Cappellini, E. Petersen, B. Moltke, I. et al. Nature 499, 74–78

N/A

N/A

mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters

Jonsson, H. Ginolhac, A. Schubert, M. Johnson, P. L. Orlando, L. et al. Bioinformatics 29, 1682–1684

N/A

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Mitochondrial phylogenomics of modern and ancient equids

Vilstrup, J. T. Seguin-Orlando, A. Stiller, M. Ginolhac, A. Raghavan, M. Nielsen, S. C. Weinstock, J. Froese, D. Vasiliev, S. K. Ovodov, N. D. et al. PLoS ONE 8, e55950

N/A

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Improving ancient DNA read mapping against modern reference genomes

Schubert, M. Ginolhac, A. Lindgreen, S. Thompson, J. F. Al-Rasheid, K. A. et al. BMC Genomics 13, 178

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2012

Improving the performance of true single molecule sequencing for ancient DNA

Ginolhac, A. Vilstrup, J. Stenderup, J. Rasmussen, M. Stiller, M. Shapiro, B. Zazula, G. Froese, D. Steinmann, K. E. Thompson, J. F. et al. BMC Genomics 13, 177

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Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins

Cappellini, E. Jensen, L. J. Szklarczyk, D. Ginolhac, A. da Fonseca, R. A. Stafford, T. W. Holen, S. R. Collins, M. J. Orlando, L. Willerslev, E. et al. J. Proteome Res. 11, 917–926

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True single-molecule DNA sequencing of a pleistocene horse bone

Orlando, L. Ginolhac, A. Raghavan, M. Vilstrup, J. Rasmussen, M. Magnussen, K. Steinmann, K. E. Kapranov, P. Thompson, J. F. Zazula, G. et al. Genome Res. 21, 1705–1719

N/A

2011

mapDamage: testing for damage patterns in ancient DNA sequences

Ginolhac, A. Rasmussen, M. Gilbert, M. T. Willerslev, E. Orlando, L. et al. Bioinformatics 27, 2153–2155

N/A

N/A

Drugs from hidden bugs: their discovery via untapped resources

Lefevre, F. Robe, P. Jarrin, C. Ginolhac, A. Zago, C. et al. Res. Microbiol. 159, 153–161

N/A

2008

Environmental metagenomics: An innovative resource for industrial biocatalysis

Lefevre, Fabrice Jarrin, Cyrille Ginolhac, Aurelien Auriol, Daniel Nalin, Renaud et al. Biocatalysis & Biotransformation 25, 242-250

N/A

2007

Type I polyketide synthases may have evolved through horizontal gene transfer

Ginolhac, A. Jarrin, C. Robe, P. Perriere, G. Vogel, T. M. et al. J. Mol. Evol. 60, 716–725

N/A

2005

Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones

Ginolhac, A. Jarrin, C. Gillet, B. Robe, P. Pujic, P. Tuphile, K. Bertrand, H. Vogel, T. M. Perriere, G. Simonet, P. et al. Appl. Environ. Microbiol. 70, 5522–5527

N/A

2004

Functional cytochrome oxidase histochemistry in the honeybee brain

Armengaud, C. Causse, N. Ait-Oubah, J. Ginolhac, A. Gauthier, M. et al. Brain Res. 859, 390–393

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2000

Hydrosoluble [6)-O- \(\alpha\) -D-Glcp-(1 \(\rightarrow\) ]\(_n\)-6-O-\(\beta\)-D-Glcp-(1\(\rightarrow\)-phenolic Derivatives With Dermocosmetic, Nutritional And Therapeutic Applications, And Compositions Containing Said Water Soluble Compounds

Auriol, D. Ginolhac, A. Lefevre, F. et al. Patent WO 2010/072754 A1,

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2010

Method For Preparing C-6 Phosphorylated D-aldohexoses And C-6 Phosphorylated D-aldohexoses Derivatives And New C-6 Phosphorylated D-aldohexoses Derivatives

Auriol, D. Nalin, R. Lefevre, F. Ginolhac, A. De Guembecker, D. et al. Patent WO 2008/142155 A3,

N/A

2009